p24 Antigen Early HIV Detection
for Infants

In developed countries, we don't understand how prevalent HIV is.  In some areas of sub-Saharan Africa, up to one third of the adult population are HIV positive which means many infants are exposed to HIV.  Infants can not be tested with standard HIV antibody tests because HIV positive mothers always pass their antibodies to the child, but not necessarily the actual virus.  This means testing must either detect the actual virus with nucleic acid testing (expensive, complicated) or with a test that detects something associated with the protein.  We opted for the latter.  

The kit consists of a lateral flow test strip, a unit dose with running buffer, a plasma separation, and off-the-shelf components to conduct the test.  The plasma separator is necessary because centrifuges and the skills to use them are unavailable in the smallest clinics served by this test.  We designed and tested all the components (consumable and device), manufactured and tested, identified production suppliers and field tested the systems.  

 

This system proved to be nearly as sensitive as nucleic acid testing in lab trials and approximately as sensitive as the adult HIV testing in the field.  Clinical trials are on-going in Zambia.

This project was done at Northwestern University with funding from Northwestern Global Health Foundation and assistance from Westberg Innovation and Silicon Engines.

I'm a Title

lynx system_edited
lynx system_edited

Lynx EID early infant diagnosis platform

press to zoom
p24 plasma separator
p24 plasma separator

filter based plasma separator for p24 EID

press to zoom
p24 herd
p24 herd

Testing of p24 devices

press to zoom
kara and lynx at moz
kara and lynx at moz

testing of p24 devices

press to zoom
2023

I'm a paragraph. Click here to add your own text and edit me. It’s easy. Just click “Edit Text” or double click me to add your own content and make changes to the font. Feel free to drag and drop me anywhere you like on your page. I’m a great place for you to tell a story and let your users know a little more about you.​

This is a great space to write long text about your company and your services. You can use this space to go into a little more detail about your company. Talk about your team and what services you provide. Tell your visitors the story of how you came up with the idea for your business and what makes you different from your competitors. Make your company stand out and show your visitors who you are.

Tip: Add your own image by double clicking the image and clicking Change Image.