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Lilly Reconstitution System

Some pharmaceuticals degrade quickly when in an aqueous solution.  When injected in a doctor's office or hospital, the reconstitution is easily done by medical professionals.  Some drugs, like human growth hormone, are administered by patients or their parents.  The drug is supplied in a freeze dried (lyophilized) form and a sterile fluid is mixed.   The original design consisted or a bare glass syringe/needle, an adapter and the drug cartridge.  A certain amount of skill was required to do it properly to avoid foaming (degrading the drug) and handling the large reconstitution needle made patients and parents nervous.  We needed to design a simpler, more user-friendly system, but the glass syringe and the drug cartridge could not change.  Our team designed several different approaches, tested them with users and created the final design.  The final design was easy to hold, allowed users to see what they needed to see, yet obscure the needle and used a side-firing needle to remove any skill required to avoid foaming.  The design won the Medical Design Excellence Award.

This work was led by Mark Fisher at IDEO.

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